TO STUDY THE ADVERSE DRUG REACTIONS (ADR) & TO FIND OUT THE EFFECT OF ADR IN TB PATIENTS REGISTERED UNDER RNTCP IN KARAD TU.

Volume : VII, Issue : VI, June - 2018

Vandana Bhoi, Anil Bhoi

BACKGROUND: Anti tubercular treatment (ATT) exhibit greater level of a efficacy with a satisfactory degree of

toxicity, however combination treatment may produce severe adverse drug reaction (ADR). ADR leads to decrease

in patient compliance & adherence .So close monitoring of ADR & it‘s effective management needed.

Objective- To study of adverse drug reactions (ADR) in tuberculosis (TB) patients registered under RNTCP and the effect of adverse drug

reaction.

Material & Methods- This is longitudinal (Prospective) study done during January2008 to June2009 Total 806 patients who registered in 9

PHCs, Sub District Hospital, Krishna Hospital & 6DMCs with 3 ICTCs under Karad TU as study subjects.

Result & Observations - It was 513 (63.6%) patients had adverse reactions while 293 (36.35%) had no adverse reactions. Out of 513

patients 486 (60.30%)had gastritis, 33 (4.09%) had gastritis and joint pain, 49 (6.09%) had gastritis and skin rash, 62 (7.69% ) had

itching, 43 (5.33%) had joint pain. Thus gastritis was being the most common adverse Conclusion- There was no any signi􀃶cantly

association seen between ADR and gender in this study. It was observed that 147(21.4%) patients continued DOTS treatment after giving

treatment for ADR, 240(34.9%) continued DOTS treatment even if they were not treated for their ADR, 301(43.8%) continued DOTS

treatment after given reassurance foe ADR.

Conclusion- Gastritis 480 (60.30%) was the most commonest adverse reaction seen as well as most of the adverse reactions was

seen in intensive phase i.e. in 􀃶rst 2 months. There was not association in ADR and gender. In this study, 147(21.4%) patients continued

DOTS treatment after giving treatment for ADR, 240(34.9%) continued DOTS treatment even if they were not treated for their ADR,

301(43.8%) continued DOTS treatment after given reassurance for ADR. Most of the adverse reactions were in intensive phase of treatment

i.e. that in 􀃶rst 2 months. Gastritis was present in intensive phase as well as initial months of continuation phase treatment.