To Observe The Efficacy Of Intravenous Magnesium Sulfate Given After Intubation And Before Creating Pneumoperitoneum To Attenuate Hemodynamic Changes Due To Pneumoperitoneum In Laparoscopic Cholecystectomy

Sai Charan Sateesh Kopparapu; Birendra Kumar Naik

Volume : IX, Issue : VI, June - 2020

To Observe The Efficacy Of Intravenous Magnesium Sulfate Given After Intubation And Before Creating Pneumoperitoneum To Attenuate Hemodynamic Changes Due To Pneumoperitoneum In Laparoscopic Cholecystectomy

Sai Charan Sateesh Kopparapu, Birendra Kumar Naik

Abstract :

In a randomized, double-blind trial study, 60 patients were divided into two groups. Group M received 50 mg/kg i.v. magnesium sulphate in 100 ml, 0.9% normal saline, Group C received the same volume of normal saline during intraoperative period. HR, MAP, Rate pressure product, were recorded prior to induction, intubation, 3 and 5 minutes post intubation, prior and during to pneumoperitoneum, 5 minutes after release of pneumoperitoneum, 5 and 10 minutes after extubation. There were sustained decreases in Systolic and Diastolic blood pressures after Endotracheal intubation in Group M in comparison to Group C contributing to lower mean arterial pressures in group M. In Group C, preinduction MAP were 13% higher than baseline. MAP increased to 25%, after extubation, which imputes stress response, but which was attenuated in group M which assures better outcome. In conclusion, Magnesium sulfate attenuated reflex tachycardia, hypertensive response, decreased RPP, and hence myocardial oxygen consumption.