To evaluate the effect of combined use of prophylactic intravenous dexamethasone and benzydamine spray on post-operative sore throat (POST) and post-operative hoarseness (PH) after intubation with double lumen tube.

Rath A.

Volume : IX, Issue : VII, July - 2020

To evaluate the effect of combined use of prophylactic intravenous dexamethasone and benzydamine spray on post-operative sore throat (POST) and post-operative hoarseness (PH) after intubation with double lumen tube.

Rath A.

Abstract :

Background and aims Post-operative sore throat and post-operative hoarseness are common after tracheal intubation. The aim of our study is to compare the effectiveness of combined use of prophylactic Intravenous dexamethasone and benzydamine hydrochloride 0.3% spray on post-operative sore throat and post-operative hoarseness after intubation with double lumen tube. Methods This study was conducted in 124 adult patients undergoing thoracic surgery using Double Lumen Tube intubation and patients were allocated into four groups, , Group A (Intravenous dexamethasone plus benzydamine hydrochloride 0.3% spray), Group B (Intravenous dexamethasone plus normal saline spray), and Group C (Intravenous normal saline plus benzydamine hydrochloride 0.3% spray), Group D (Intravenous normal saline plus normal saline spray). Post-operative sore throat and post-operative hoarseness were evaluated at one, six and 24h after surgery. Sore throat was evaluated using a 0-100 mm visual analogue scale. Hoarseness was deﬁned as a change in voice quality. Results The incidence of post-operative sore throat and post-operative hoarseness as well as severity were significantly lower in Group A compared to other groups (p<0.01). The incidence of post-operative sore throat and post-operative hoarseness was significantly lower in Group B and C than Group D (P<0.01). However, there was no statistical difference between Group C and Group B (P>0.005). Conclusions Prophylactic application of intravenous dexamethasone and benzydamine spray to the double lumen tube cuff and oropharyngeal cavity reduces the incidence and severity of postoperative sore throat and the incidence of hoarseness associated with DLT intubation.