To evaluate the association between clinical parameters of chronic urticaria and various biomarkers

Dr Seema Rani; Dr Niharika Dixit; Dr Devika Choudhry; Dr P.K. Sharma

Volume : VIII, Issue : XI, November - 2019

To evaluate the association between clinical parameters of chronic urticaria and various biomarkers

Dr Seema Rani, Dr Niharika Dixit, Dr Devika Choudhry, Dr P. K. Sharma

Abstract :

Introduction Causes of chronic urticaria (CU) remain obscure. Laboratory parameters or biomarkers can be a predictor of duration and severity of Urticaria. Objective The aim of this study was to evaluate the association between clinical parameters of chronic urticaria and various biomarkers. Methods A retrospective cross-sectional data of 134 patients of chronic urticaria seen in allergy-clinic, during recent 2 years span were collected. Demographic details, duration of the disease, urticaria activity score (UAS), Autologus serum skin test (ASST) and various autoimmune and inflammatory laboratory parameters were included. Results We found disease activity (UAS) was significantly associated with biomarkers, ASST (.044), CRP (.025) and ANA (.000). ANA positivity was significantly (.000) associated with duration of the disease. Conclusions The present study found association of chronic urticaria with inflammatory and autoimmune markers; hence it is important to monitor certain laboratory testings like, CRP, ESR, ANA, ASST, Thyroid auto antibodies, IgE and routine blood count to predict the disease duration, severity and to manage patients appropriately.