The saga of Reactive Thrombocytosis And Its relationship with Hematological Parameters, Acute Phase Reactant, C-Reactive Protein In Different Clinical Conditions-three year study in north east region of India.

Dr (Lt Col) Navneet Anand; Dr (Maj) Ragini Thapa

Volume : IX, Issue : VI, June - 2020

The saga of Reactive Thrombocytosis And Its relationship with Hematological Parameters, Acute Phase Reactant, C-Reactive Protein In Different Clinical Conditions-three year study in north east region of India.

Dr Lt Col Navneet Anand, Dr Maj Ragini Thapa

Abstract :

Background- Thrombocytosis is aptly defined as platelet count greater than a defined upper limit of normal that may vary between 350,000/μl to 550,000/μl, depending on the laboratory or medical reference. Elevated platelet counts are often an incidental or unexpected finding on a complete blood count conducted to evaluate an unrelated condition.The platelet parameters and reactive protein (CRP) are marker s reflecting asystemic inflammatory response. Among those ,CRP is one of the major proteins helpful in determination of severity/ activity of chronic spontaneous processes. Aim: The measurements of platelet count, mean platelet volume (MPV), WBC are routinely available nowadays. The aim of the study was to know the association of reactive thrombocytosis in different underlying clinical conditions, age dependent aetiology, WBC count, ESR and C-REACTIVE PROTEIN in inflammatory disease and platelet volume.. Methods: This descriptive study was done on 500 patients with platelet count > 450,000/ μl and the cause being reactive. Platelet count, WBC, MPV, ESR, and CRP were measured at the time of hospitalization. Results. No significant differences were found in MPV and PDW between CSU group and the healthy subjects. Most common cause of reactive thrombocytosis was found to be infection (28.8%), tissue damage (16.4%), iron deficiency anemia (16.2%), malignancy (9.6%), inflammation (non-tuberculosis) (9.4%), diabetes mellitus (6.4%), tuberculosis (6.0%) respectively. There was low degree of positive correlation between reactive thrombocytosis with WBC (r = 0.337, P= 0.06) and ESR (r = .277, P= >0.05). There was low degree of negative correlation between reactive thrombocytosis and CRP (r= -.131, P= >0.05). There was significant negative correlation between reactive thrombocytosis and MPV (r = -.561, P= >0.001). Conclusion: Thrombocytosis is associated with the increased number of circulating platelets in patients with more severe symptoms. This study demonstrated a higher level of platelet count and lower MPV in all the patients having reactive thrombocytosis. The changes in these parameters (platelets count, WBC, MPV, CRP and ESR) may reflect a reaction to the inflammatory condition.