The Role of Topical Vitamin C Administration on Healing Mid-Dermal Burns in Wistar rats

Fajar Dwijayanto; Utama Abdi Tarigan; Frank Bietra Buchari

Volume : IX, Issue : V, May - 2020

The Role of Topical Vitamin C Administration on Healing Mid-Dermal Burns in Wistar rats

Fajar Dwijayanto, Utama Abdi Tarigan, Frank Bietra Buchari

Abstract :

Introduction: A burn is a trauma caused by heat, cold, electric current, chemicals, gas, lightning, and radiation (including sunlight). Water-soluble Vitamin C helps in the process of collagen synthesis and enhances the defense mechanism of the immune system and facilitates wound healing. We aim to see the effect of topical vitamin C administration on healing mid-dermal burns in Wistar rats. Material Methods: Experimental studies to assess the effect of vitamin C administration on wound healing in second-degree (dermal) burns in Wistar rats. The research design used a simple experimental design (Post Test Only Control Group Design). This research was conducted at the Laboratory of Animal Pharmacy, Faculty of Pharmacy, University of North Sumatra, Medan, in October - November 2018. Result: The group given topical vitamin C had an average burn area of 304.6 � 31.5 compared to the control group given normal saline with 433.4 � 32.2. Based on statistical tests, the value of p <0.001 was concluded, so there were significant differences between the two groups (p <0.05) between topical vitamin C compared with those not given topical vitamin C to increase collagen deposition in mid-dermal burns on the 14th day. The provision of topical vitamin C gives better results than just the administration of saline. On the 14th-day post-burn induction, the burn area in the topical vitamin C group was reduced by 39.4% while in the control group, it was only 10.7%. Conclusion: Based on the results of research that has been done it can be concluded that Topical vitamin C can accelerate healing and reduction in burn area based on macroscopic observations on day 14 in Wistar rats compared to control groups that are only given normal saline. Based on statistical tests, it was found that p-value <0.001 so that it was concluded that there were significant differences in the average of the two groups (p <0.05) on the increase in collagen deposition in mid dermal burns.