THE ROLE OF D-DIMER LEVELS AS A MARKER OF NEONATAL SEPSIS

Annette Regina Brahmana; Bugis Mardina Lubis; Muhammad Ali

Volume : VIII, Issue : VI, June - 2019

THE ROLE OF D-DIMER LEVELS AS A MARKER OF NEONATAL SEPSIS

Annette Regina Brahmana, Bugis Mardina Lubis, Muhammad Ali

Abstract :

Sepsis is a major cause of neonatal morbidity and mortality. One complication of sepsis is coagulation dysfunction. Coagulation dysfunction is a complication of neonatal sepsis that can manifest clinically or subclinically in intravascular coagulation. D-dimer, a crosslinked fiin degradation product, is increased in neonates with sepsis. A diagnostic study with cross-sectional design was conducted in October until December 2018 among 34 neonates with sepsis in the neonatology unit of General Hospital Center Haji Adam Malik Medan. In this study, D-dimer and blood culture were examined. A diagnostic test is to define value of D-dimer sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio. There are 24 subjects with D-dimer levels <0.3 mg%. The sensitivity was 28%, specificity 70%, positive predictive value 40%, negative predictive value 58%, positive likelihood ratio 0.95 and negative likelihood ratio 1.02. D-dimer level is not a useful marker for neonatal sepsis.