The Impact of Aggressive Parenteral Amino Acid Administration on Blood Urea Nitrogen Level in Preterm Neonates

Nikmah F.M lubis; Bugis Mardina Lubis; Wisman Dalimunthe

Volume : VIII, Issue : VII, July - 2019

The Impact of Aggressive Parenteral Amino Acid Administration on Blood Urea Nitrogen Level in Preterm Neonates

Nikmah F. M Lubis, Bugis Mardina Lubis, Wisman Dalimunthe

Abstract :

Conventional parenteral amino acid for preterm neonate is initiated in several days after birth with a low starting dose. It is caused by a concern regarding the elevation of Blood Urea Nitrogen (BUN) from aggressive amino acid administration. It causes negative nitrogen balance and impairs growth and development of the neonate. Objective: To determine the impact of aggressive parenteral amino acid administration on BUN level in preterm neonates. Method: A total of 38 subjects were enrolled in this study based on inclusion and exclusion criteria. Subjects were randomized into control and intervention groups. Control and intervention groups received parenteral amino acid at starting dose of 1.5 g/kgBW/day and 3 g/kgBW/day, respectively, which were increased gradually in 3 days. BUN level was measure on the first and third day. Data was analyzed using computer software and p value of <0.05 was considered significant. Results: Higher BUN level was observed in control group (10.4 mg/mL) compared to intervention group (8.2 mg/mL). Weight increment was more prominent in intervention group (20 g) compared to control group (0 g). There was no significant association between the method of amino acid administration and BUN level (p = 0.562). There was no significant correlation between total amino acid intake and BUN level (p = 0.108). Conclusion: There is no impact of aggressive parenteral amino acid administration on BUN level in this study.