THE EFFECTS of PREGABALINE TREATMENT on BASAL TEARS RELEASE and TEARS FILM STABILITY in FIBROMYALGIA PATIENTS WITHOUT DRY EYE SYNDROME

Gulsah Usta; Bekir Eray Kilinc

Volume : VI, Issue : IX, September - 2017

THE EFFECTS of PREGABALINE TREATMENT on BASAL TEARS RELEASE and TEARS FILM STABILITY in FIBROMYALGIA PATIENTS WITHOUT DRY EYE SYNDROME

Gulsah Usta, Bekir Eray Kilinc

Abstract :

To evaluate ocular surface disease index, basal secretion test and tear eakup time test of pregabalin treatment in patients with FM without dry eye syndrome.

Materials and Method:

66 patients who met the study criteria between December 2014 and December 2016 were included. OSDI (Ocular Surface Disease Index) questionnaire showing qualitatively dry eye presence and severity, Schirmer and tear eakup time (T-BUT) tests were administered to all patients included in the study before the start of pregabalin treatment, in the second week and the second month during treatment. Data of the radiological and clinical evaluations in preoperative and follow-up periods were compared statistically. Statistical significance was accepted at p<0.05.

Results:

The mean age of all patients was 40.48�7.6 years. Mean age of the 12 males was 30.3�5.2 and 42.4�7.6 of the 44 females. OSDI scores averaged 18.83�8.23, 19.12�9.37, 19.06�12.78 for pre-treatment and after 2 weeks and 2 months of drug use, respectively. No significant statistical difference was found between these values (p = 0.58). The mean values of Schirmer test scores, pre-treatment, post-treatment second week and second months values were 17.46�3.5, 17.78�2, and 17.51�3.5, respectively, which were not statistically significant (p = 0.76). The mean values of t-BUT scores were 11.56�0.5, 11.45�0.5, 11.83�0.4 for pre-treatment and after 2 weeks and 2 weeks of treatment, respectively. Changes in t-BUT values were not statistically significant (p = 0.62).

Conclusion:

The use of pregabalin is a safe and effective method for tear release in the treatment of patients with FM who have not received dry eye diagnosis before the age of 50 years.