THE ASSOCIATION OF ANTIEPILEPTIC DRUGS WITH VITAMIN D STATUS IN CHILDHOOD EPILEPSY

Ratna Suwita Batubara; Johannes Harlan Saing; Yazid Dimyati; Cynthea Prima Destariani

Volume : VIII, Issue : XII, December - 2019

THE ASSOCIATION OF ANTIEPILEPTIC DRUGS WITH VITAMIN D STATUS IN CHILDHOOD EPILEPSY

Ratna Suwita Batubara, Johannes Harlan Saing, Yazid Dimyati, Cynthea Prima Destariani

Abstract :

Background:Epilepsy is a common neurological disorder of childhood requiring long term of antiepileptic drugs that has been associated with low 25-hydroxyvitamin D (25(OH)D) status and high prevalence of vitamin D deficiency. However, studies on the effect of long term antiepileptic drugs use on vitamin D had inconsistent results. The aim of this study was to analyze the association of antiepileptic drugs (AED) with vitamin D status in childhood epilepsy. Methods: A cross sectional study was conducted from Feuary to April 2019 at children outpatient clinic Haji Adam Malik Hospital. One hundred and two epileptic children taking antiepileptic drug were enrolled consecutively. All cases who met inclusion criteria, underwent test for serum 25(OH)D that were categorized as normal (≥30 ng/ml) and abnormal (<30 ng/ml). Antiepileptic drugs were categorized based on their enzyme inducing properties, polytherapy combination and monotherapy. Results: From 102 patients, 77 children (75.5%) had abnormal vitamin D with average level of 25(OH)D was 24.37 ng/ml (SD 9.23). The mean of age was 9.26 years (SD 4.96), 57.8% were boy and 79.4% on monotherapy. Association between enzyme inducing vs non-inducing properties, monotherapy vs polytherapy and duration of therapy with vitamin D status were non significance with p value 0.277, 0.713 and 0.728 respectively. Sodium Valproate was the most common AED used in mono therapy (87.7%) and combination of Sodium Valproate-Topiramate in polytherapy (42.9%). The differences of an abnormal vitamin D in those on AED as monotherapy were not significant (p=0.713). Similarly in polytherapy, there were non-significant difference of vitamin D level in each combination of AED (p=1). Conclusion: There was no significant association of antiepileptic drugs with vitamin D status in childhood epilepsy. This study was presented as poster presentation at the 15th Asian Oceanian Congress of Child Neurology, Kuala Lumpur, Malaysia, September 2019