Synthesis  EPR study and biological evaluation of four  co-ordinate complex and heterocyclic base adducts of Cu (II) derived from N(4) thiosemicarbazone

J. R. Gujarathi

Volume : IV, Issue : XII, December - 2015

Synthesis EPR study and biological evaluation of four co-ordinate complex and heterocyclic base adducts of Cu (II) derived from N(4) thiosemicarbazone

J. R. Gujarathi

Abstract :

Ni (II) complex and adducts have been synthesized by reacting the Ni (II) chloride with 3,5-dichloro 2-hydroxy acetophenone N(4) methyl thiosemicarbazone and in presence of heterocyclic bases like pyridine (py),2-chloropyridine, 3-chloropyridine and 4-chloropyridine Thiosemicarbazone has been characterized by 13C, 1H NMR as well as IR, electronic spectra and EI-MS. The synthesized complex and adducts were characterized by elemental analysis, IR, electronic spectroscopy,EI-MS as well as by TGA, magnetic and conductivity measurement. The magnetic and spectroscopic data indicated square planer geometry for the four coordinate complex and adducts. Antimicrobial assay has also been carried out for synthesized compounds. The thiosemicarbazone and its metal complexes showed growth inhibitory activity against Staphylococcus aureu,Bacilus subtilis(Gram+ve), Escherichia Coli,Peudomonas aeruginosa (Gram-ve) bacterial species.