Volume : IV, Issue : IV, April - 2015

Synthesis, characterisation and antimicrobial studies of 2-[(morpholin-4-yl)(pyridin-3-yl)methyl] hydrazinecarboxamide and its transition metal(II) complexes

S. Farook Basha, M. Syed Ali Padusha

Abstract :

<p> CoII, NiII, CuII and MnII complexes of Mannich base, as ligand, was prepared by condensation of aqueous semicarbazide, </p> <div>morpholine and pyridine–3–carboxaldehyde. The structure of the newly synthesized Mannich base was investigated by </div> <div>UV–Vis, IR, 1</div> <div>H–NMR, 13C–NMR, molar conductance and magnetic susceptibility studies. The antimicrobial activities of the </div> <div>ligand and metals complexes have been screened in vitro against the organisms E.faecalis, Proteus mirabilis, Bacillus cereus, E.aerogens, ESBL </div> <div>E.coli, ESBL K.pneumoniae, by disc diffusion and well diffusion techniques. It is observed that the coordination of metal ions has pronounced </div> <div>effect on the microbial activities of the ligand. The metal complexes have higher antimicrobial effect than the free ligand.</div>

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

S. Farook Basha, M. Syed Ali Padusha Synthesis, characterisation and antimicrobial studies of [(morpholin–4–yl) (pyridin–3–yl) methyl] hydrazinecarboxamide and its transition metal(II) complexes Global Journal For Research An

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