STUDY OF TUBERCULOSIS AND CRYPTOCOCCAL MENINGITIS IN HIV INFECTED PATIENTS AND THEIR CORRELATION WITH CD4 COUNT

Dr. Rita Singh Saxena; Dr. Anita Arya

Volume : VI, Issue : XII, December - 2017

STUDY OF TUBERCULOSIS AND CRYPTOCOCCAL MENINGITIS IN HIV INFECTED PATIENTS AND THEIR CORRELATION WITH CD4 COUNT

Dr. Rita Singh Saxena, Dr. Anita Arya

Abstract :

Aim To study clinical and CSF profile of Tubercular and Cryptococcal meningitis in HIV infected hospitalised patients and to correlate clinical profile with CD-4 count.

Methodology All the admitted HIV positive patients whose clinical manifestations were suggestive of meningitis, were screened by CSF analysis and specific diagnosis made according to CSF findings. CSF-AFB stain, CSF cultur , and india ink preparation were also done to make the diagnosis more accurate. CD-4 count of every HIV sereopositive meningitis patients was determined using flow-cytometry

Results In our study, thirty seven meningitis patients were HIV positive. Patient�s age ranges from 20-70 years. We found only two types of meningitis in our study- Tubercular meningitis and Cyptococcal meningitis. 81.08% of patients had Tubercular meningitis and 18.91% of patients had Cyptococcal meningitis in our study. Tubercular meningitis was significantly more common than Cryptococcal meningitis.

Conclusion HIV infected patients are at high risk for opportunistic infections including meningeal involvement. Severe manifestations of meningitis keeps on increasing with decrease in CD-4 count. By early diagnosis and management of HIV positive patients with HAART- Highly Active Anti Retroviral Therapy we can keep CD-4 count of patient elevated to prevalent TB meningitis and Cryptococcal meningitis and also the sequel of disease.