STUDY OF SERUM INSULIN LEVEL AND ESTIMATION OF INSULIN RESISTANCE BY HOMA-IR METHOD IN PATIENTS OF BENIGN ESSENTIAL HYPERTENSION

Dr Nupur Srivastava; Dr PK Khodiar

Volume : VI, Issue : III, March - 2017

STUDY OF SERUM INSULIN LEVEL AND ESTIMATION OF INSULIN RESISTANCE BY HOMA-IR METHOD IN PATIENTS OF BENIGN ESSENTIAL HYPERTENSION

Dr Nupur Srivastava, Dr Pk Khodiar

Abstract :

Hyperinsulinemia syndrome describes four conditions�insulin resistance, hyperlipidemia, abdominal obesity, and hypertension�that occur more frequently together than chance alone would dictate. Secondary effects from hyperinsulinemia may cause blood pressure elevations; in fact, hyperinsulinemia is strongly correlated with the development of essential hypertension. Hyperinsulinemia is considered to cause blood pressure elevation and is generally accepted as an independent risk factor for atherosclerosis. It has been revealed previously that insulin-mediated glucose uptake was reduced by 40% in subjects with hypertension. Approximately 50% of hypertensive patients are insulin resistant and these subjects are at great risk of cardiovascular disease. Thus, hypertensive patients with insulin resistance represent a particular disease group and require special medical attention in daily practice.

Hence this study is aimed to emphasize how common insulin resistance is in patients with essential hypertension and to reemphasize the need to initiate intensive efforts aimed to improve insulin sensitivity and treating all of the CVD risk factors in patients with essential hypertension, not just the blood pressure.