STUDY OF RENAL BIOPSY IN SYSTEMIC LUPUS ERYTHEMATOSUS

Dr. Nitin G. Tiple; Dr. Vinod  K. Sawaitul; Dr. Shashikant V. Dhoble; Dr. Shital S. Dhoble

Volume : V, Issue : X, October - 2016

STUDY OF RENAL BIOPSY IN SYSTEMIC LUPUS ERYTHEMATOSUS

Dr. Nitin G. Tiple, Dr. Vinod K. Sawaitul, Dr. Shashikant V. Dhoble, Dr. Shital S. Dhoble

Abstract :

Background: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory multisystem autoimmune disease primarily affecting women of reproductive age. It is a disease characterized by the production of auto antibodies to components of the cell nucleus in association with a diverse array of clinical manifestations. The primary pathological findings are those of inflammation, immune complex deposition, vasculopathy and very rarely vasculities1,2. Objective: The main purpose of this study is the role of renal biopsy for the diagnosis of LN, interpretation of activity and chronicity indices for the staging of LN to know its prognostic importance in subsequent management of SLE. Materials and Methods: 3 year study of renal biopsy in 101 cases of SLE was conducted in tertiary care hospital in Mumbai. Tissue were processed, stained and studied under microscope. Results were analysed and tabulated. Results: Most commonly found in females (93.9%), amongst young adults between 21-30 years age group, Class IV/diffuse lupus nephritis (84.84%) followed by Class III/focal lupus nephritis (6.06%) are most commonly evident, activity index in class IV were Interstitial Inflammation (67.86%). Conclusion: Kidney biopsy helps to diagnose the disease process, assess the course of progression and to decide the treatment plan of SLE