STUDY OF LIVER FUNCTION TEST AND LIPID PROFILE IN ALCOHOLIC LIVER DISEASE

Ashit Kumar Bairagi; Prabir Kumar Ganguly

Volume : IX, Issue : VII, July - 2020

STUDY OF LIVER FUNCTION TEST AND LIPID PROFILE IN ALCOHOLIC LIVER DISEASE

Ashit Kumar Bairagi, Prabir Kumar Ganguly

Abstract :

BACKGROUND:Alcoholic cirrhosis is quite often associated with impaired lipid metabolism.The aim of the study was to assess the degree of alteration of serum lipid profile in alcoholic cirrhotic patients and also to detect its association with the patients�s age and the pattern of alcohol consumption . METHOD:This cross-sectional study was conducted in COM &JNM Hospital, Kalyani, Nadia, West Bengal for 1year on 50 cases with history of alcohol consumption. A questionnaire based on history of alcohol intake was made for each patient. LFT and Serum lipid profile (total, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol and triglyceride) was recorded for each case and control. t test of significance was applied for statistical analysis. RESULT: Majority of the cases were in the 40-49 years age group. The study found a definite relationship with the quantity and the duration of alcohol consumption. In patients with cirrhosis, decrease in the total serum cholesterol level was noted. A significant decrease in serum HDL and LDL cholesterol was observed ( P < 0.001). However, there were significant increase in the serum triglyceride levels in alcoholic cirrhotic patients compared with the control group ( P < 0.001). CONCLUSION:In this study, we found that there was marked alteration of LFT and serum lipid profile values in patients with alcoholic cirrhosis. Therefore, a search for lipid profile abnormality along with LFT should be performed in every cirrhotic patient.