STUDY OF LEVEL OF SERUM LOW DENSITY LIPOPROTEIN (LDL) CHOLESTEROL IN PATIENTS WITH HELICOBACTER PYLORI INFECTION

Aman Gupta; Abhinav Gupta; R.P.Kudyar; Rohit Raina; Sahil Mushtaq

Volume : IX, Issue : V, May - 2020

STUDY OF LEVEL OF SERUM LOW DENSITY LIPOPROTEIN (LDL) CHOLESTEROL IN PATIENTS WITH HELICOBACTER PYLORI INFECTION

Aman Gupta, Abhinav Gupta, R. P. Kudyar, Rohit Raina, Sahil Mushtaq

Abstract :

Objective – To study the level of serum LDL cholesterol in patients with H. Pylori infection and compared with control group who are age and BMI matched. Material & methods - This study was prospectively conducted on age and BMI matched 60 patients (30 cases and 30 controls) presented to the Department of Medicine in Acharya Shri Chander College of Medical Sciences and Hospital, Sidhra, Jammu from november 2009 to October 2010 with the chief complaints of upper gastrointestinal symptoms. 60 patients enrolled in the study were divided into cases and control depending upon rapid urease test .The baseline characteristics of age, sex, height, weight and BMI were comparable in two groups. The maximum number of patients in group I (cases) was in age group of 35-45 years and in group II (control) in 25-35 years. 30 males and 30 females were recruited in whom mean height, weight and BMI were statistically insignificant. Among laboratory parameters, fasting plasma sugar and fasting serum lipid profile were estimated. We excluded the patients who had risk factors for dyslipidemia in order to be able to clearly assess whether infection with H.pylori raises serum LDL cholesterol of patients or not. The Statistical Package for Social Sciences (SPSS) version 13.0 was utilized to analyze the results. Parametric variables are presented as means  standard deviation . An analysis using the Spearman Correlation was performed to evaluate the existence of associations between H.pylori infection and LDL levels. Logistic Regression analysis, involving the statistically significant variables identified by the Spearman Correlation was performed to evaluate the probability of raised LDL levels in presence of H.pylori infection investigated in this study. Chi square test is used to analyses the number of patients in two groups and �t� test for equality of means. P.values < 0.05 were considered statistically significant. Results- The difference in fasting plasma sugar level in two groups was statistically insignificant, but marked variability was seen in levels of serum lipid profile. The level of serum total cholesterol in cases v/s control group was significantly high 205.93 � 13.17 mg/dl v/s 169.27 � 16.44. Similar significant rise in the levels of serum LDL cholesterol was noted in cases (134.53 � 11.88 mg/dl) v/s control (98.30 � 13.78 mg/d1), The difference in the levels of I-IDL cholesterol and triglycerides was statistically insignificant in the two groups. Conclusion- The study found an association between H. pylori infection and altered serum lipid profiles. Infected subjects have a significant increase in total cholesterol and LDL cholesterol levels compared to uninfected subjects. In view of the gravity of acute coronary events and salvageability on timely management, the infection with H. pylori can be a modifiable risk factor and further studies are needed to see the impact of early treatment of infection on acute coronary events.