Volume : VII, Issue : I, January - 2018

Study of association of leptin and insulin resistance markers in patients of PCOS

Huma Nasrat

Abstract :

 

Polycystic ovary syndrome (PCOS)the most common endocrine disorder , PCOS may present with hirsutism, acne,  excessive androgen production, menstrual disturbances and subsequently, anovulation and infertility.

Leptin, a peptide hormone secreted from adipose tissue. Insulin resistance and hyperinsulinemia may also be factors that affect serum leptin levels.Aim of this study is to evaluate the association of leptin and insulin resistance markers in patients of PCOS.

SUBJECT AND METHOD:Sixty diagnosed cases of PCOS were enrolled in this study after informed written consent. The patients were diagnosed as PCOS as per Rotterdam criteria

All  routine biochemical investigation were done.Insulin resistance was estimated using the homeostatic model assessment-insulin resistance (HOMA-IR) and HOMA-beta. HOMA-IR  insulin levels and serum leptin levels was measured

RESULT We found correlation between leptin and various insulin resistance markers although not significant

Keywords :

Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Huma Nasrat, Study of association of leptin and insulin resistance markers in patients of PCOS, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-7, ISSUE-1, JANUARY-2018

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