STRUCTURE BASED VIRTUAL SCREENING FOR IDENTIFICATION OF NOVEL SURVIVN INHIBITOR FOR ANTICANCER

Ganesan Vijayansiva; Ramarajan Sivasankaran

Volume : IV, Issue : VII, July - 2015

STRUCTURE BASED VIRTUAL SCREENING FOR IDENTIFICATION OF NOVEL SURVIVN INHIBITOR FOR ANTICANCER

Ganesan Vijayansiva, Ramarajan Sivasankaran

Abstract :

Survivin is one of the most cancer-specific proteins identified to date, being upregulated in almost all human tumors. Biologically, survivin has been shown to inhibit apoptosis, enhance proliferation and promote angiogenesis. Because of its upregulation in malignancy and its key role in apoptosis, proliferation and angiogenesis, survivin is currently attracting considerable attention as a new target for anti-cancer therapies. In these studies to identify potential inhibitor through virtual screening, molecular docking and ADME toxicity analysis revealed 2 hits compound with good docking score and included in ADME properties.