Solid as Solvent - Melted dimethyl urea as solvent to analyse indomethacin capsules spectrophotometrically at 265 nm (Mixed solvency concept)

Maheshwari R.K; Padiyar.A

Volume : VIII, Issue : XII, December - 2019

Solid as Solvent - Melted dimethyl urea as solvent to analyse indomethacin capsules spectrophotometrically at 265 nm (Mixed solvency concept)

Maheshwari R. K, Padiyar. A

Abstract :

In the current attempt of research, novel method for spectrophotometric estimation of indomethacin in capsules using melted dimethyl urea as solvent was developed. The main objective behind research is to show �SOLIDS ALSO POSSESS SOLUBILIZING POWER�. The current study deals with novel spectrophotometric analytical technique for quantitative estimation of indomethacin in capsules using melted dimethyl urea as solvent. According to the theory proposed byMaheshwari, each& every substance possessessolubilising power, susbstance may be a gas, solid or liquid. Dimethyl ureaimbibes large solubilizing power to indomethacin and having approximate solubility more than 800 mg per gm of melted dimethyl urea whereas aqueous solubility of indomethacin is 0.36 mg/ml at room temperature. Caliation curve of indomethacin was plotted by recording the absorbances of standard solutions of drug. The absorbances were observed at 265 nm against respective reagent blanks.The percent label claims were found very close to 100 (99.33 � 1.112 and 98.07 � 1.843) indicating accuracy of the proposed method.Percent recoveries estimated by the proposed method are close to 100 with significant low values of percentage deviation and standard error.Thus, it may be concluded that proposed method is simple, safe and precise and excludes use of toxic organic solvents.