Serum uric acid as a marker of pregnancy induced hypertension and its association with uterine atony in pre-eclamptic patients undergoing elective caesarean section under spinal anesthesia.

Sheikh Irshad Ahmad; Shaista Yaqoob; Tantry Tariq Gani; Tanveera Gani; Syed Yusra Imtiyaz

Volume : IX, Issue : VIII, August - 2020

Serum uric acid as a marker of pregnancy induced hypertension and its association with uterine atony in pre-eclamptic patients undergoing elective caesarean section under spinal anesthesia.

Sheikh Irshad Ahmad, Shaista Yaqoob, Tantry Tariq Gani, Tanveera Gani, Syed Yusra Imtiyaz

Abstract :

Introduction: Serum uric acid is a marker for oxidative stress in preeclampsia. Recent retrospective studies have associated hyperuricemia with decreased uterine contractility Because oxidative stress can result in diminished uterine contractility and impaired vascular relaxation. The study was aimed to study association of elevated serum uric acid level in women undergoing neuraxial anesthesia for cesarean delivery with greater uterine atony, as measured by supplemental uterotonic agent use. Methods: 204 patients with pregnancy induced hypertension scheduled for elective caesarean section under spinal anesthesia were included in the study. Demographic data, medical and obstetric history, anesthetic management and peripartum course were recorded. Serum uric levels were measured within 24 hours of caesarean delivery. Dose of uterotonic agents received was recorded in all patients. The association between serum uric acid level and uterotonic agent use was studied. Data was analysed using students t test and chi-square test. Results: 72 patients required 20 IU oxytocin has lower serum acid levels (4.6444�1.74169 ) than 132 patients who required >20 IU of oxytocin(6.6073�1.36146 ) (p value <0.001).In patients requiring more than 20 IU oxytocin, patients requiring 30 IU of oxytocin had higher serum uric acid levels than those requiring 25 IU of oxytocin. The difference in serum uric acid was statistically highly significant.(p-value < 0.001) Conclusion: Elevated serum uric acid in parturients undergoing cesarean delivery with neuraxial anesthesia was associated with increased use of supplemental uterotonic agents.