Serum Uric acid : A biomarker for acute exacerbation of COPD

Dr. Gulab Kanwer; Dr. Suman Meena; Dr. Hariom Meena

Volume : IX, Issue : V, May - 2020

Serum Uric acid : A biomarker for acute exacerbation of COPD

Dr. Gulab Kanwer, Dr. Suman Meena, Dr. Hariom Meena

Abstract :

Introduction: Airway inflammation and imbalance between oxidant/antioxidant mechanisms are postulated to play a major role in the pathogenesis and exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Serum uric acid is increased in hypoxic state as well as in systemic inflammation including patients with COPD. Aims and Objectives: To measure the serum uric acid levels among COPD subjects and to correlate with different stages of the disease. Material and Methods: The study included 40 stable COPD subjects (21 males, 19 females; 13 smokers, 27 nonsmokers; age group; 35 to 60 years) was admitted in MBS hospital in Kota and compared with 45 control subjects from the population. Serum UA levels were measured by enzymatic colorimetric assay in fully analyser (Erba EM 360, Roche, Germany) using commercially available kits from Roche. This study was further correlated with duration and severity of COPD. (as per Global Initiative for Obstructive Lung Disease (GOLD) criteria. Results: The mean age of COPD and control subjects was 61.07�10.30 and 47.73�11.61 years, respectively (p<0.001). COPD cases had significantly higher level of UA compared to control subjects (5.85�1.67 vs. 2.02�0.83 mg/dl, respectively, p<0.001). Female subjects with COPD had higher levels of UA compared to their male (6.15�1.88 vs. 4.49�1.35 mg/dl, respectively, p=0.333). Similar insignificant (p=0.53) trend was also observed among control subjects. Hyperuricaemia correlated significantly (p< 0.05) with advance duration (≥ 10 years) of COPD; whereas, statistically insignificant trend was observed for GOLD stage 3/4 versus stage 1/2 disease. Conclusion: Serum uric acid is a simple and cost effective biochemical test which play role in risk stratification of subjects with new diagnosed COPD. Hyperuriceamia is associated with advanced disease duration and stages of COPD.