Role of Unfolded Protein Response in Cardiac Diseases.

Smita Sharma; Rami Abdullah Ali Al Dagrer; SK Mathur; Ramesh Maheshwari; Simmi Kharab

Volume : VIII, Issue : XII, December - 2019

Role of Unfolded Protein Response in Cardiac Diseases.

Smita Sharma, Rami Abdullah Ali Al Dagrer, Sk Mathur, Ramesh Maheshwari, Simmi Kharab

Abstract :

Cardiovascular disease is the leading cause of death worldwide. Multiple forms of the cardiovascular disease involve acute or chronic disturbance in cardiac myocytes, which may lead to potent activation of the unfolded protein response (UPR), a cellular adaptive reaction to accommodate protein-folding stress. Ample evidence has firmly established that the UPR is strongly induced in heart disease. Recently, the mechanism of action and multiple pharmacological means to favorably modulate the UPR are emerging to curb the initiation and progression of cardiovascular disease.In this review we tried to focus the unfolded protein response in cardiovascular disease. Modulating the UPR may be clinically beneficial. For example, in heart failure, UPR activation contributes to arrhythmic risk and inhibiting the UPR may decrease that risk. Targeting the UPR seems to be a potentially fruitful approach in novel therapeutics for cardiac disease.