ROLE OF SILDENAFIL CITRATE AND ESTRADIOL VALERATE COMPARED WITH ONLY ESTRADIOL VALERATE IN THE TREATMENT OF THIN ENDOMETRIUM IN CASES OF CONTROLLED OVARIAN HYPERSTIMULATION WITH INTRAUTERINE INSEMINATION.

Dr Ayesha Ansari; Dr Archana Bhosale

Volume : VIII, Issue : VII, July - 2019

ROLE OF SILDENAFIL CITRATE AND ESTRADIOL VALERATE COMPARED WITH ONLY ESTRADIOL VALERATE IN THE TREATMENT OF THIN ENDOMETRIUM IN CASES OF CONTROLLED OVARIAN HYPERSTIMULATION WITH INTRAUTERINE INSEMINATION.

Dr Ayesha Ansari, Dr Archana Bhosale

Abstract :

Background : Improving endometrial thickness(ET) is one of the cornerstone treatment in the management of infertility requiring precision in the drug dosages and routes. Estradiol valerate has been a known hormone to increase thickness whereas this study focusses on the addition of sildenafil citrate per vaginal to further improvise the ET. Materials : A randomized controlled study of 50 pts in the estradiol only group and 50 pts in the estradiol + sildenafil group were studied in pts undergoing Controlled Ovarian Hyperstimulation with Intrauterine IUI. Results : Sildenafil citrate with Estradiol valerate group showed a significant increase in ET , sub-endometrial blood flows, and endometrial pattern, thus increasing the clinical pregnancy rates. Conclusion: Sildenafil citrate should be included as a routine to improve ET along with Estradiol valerate in the treatment of pts with thin endometrium