Role of Neoadjuvant Chemotherapy Followed by Chemoradiotherapy In Locally Advanced Carcinoma of Cervix: An Institutional Study

Dr Mahesh Rewadkar; Dr S. O. Kothari

Volume : VII, Issue : VIII, August - 2018

Role of Neoadjuvant Chemotherapy Followed by Chemoradiotherapy In Locally Advanced Carcinoma of Cervix: An Institutional Study

Dr Mahesh Rewadkar, Dr S. O. Kothari

Abstract :

Introduction:Cancer refers to a class of diseases in which a cell or a group of cells divide and replicate uncontrollably, intrude into adjacent cells and tissues (invasion) and ultimately spread to other parts of the body than the location at which they arose (metastasis). The definition of NACT in cervical cancer is the administration of chemotherapy for the purpose of reducing the cancer volume before the main treatment.

Methodology:Retrospective study conducted in a tertiary care centre from August 2012 to August 2017 including 95 patients of locally advanced Ca Cervix.

Results: Improvement in DFS and OS with Neoadjuvant chemotherapy noted.

Discussion:The study has demonstrated a good response rate to NACT followed by CRT in patients with locally advanced carcinoma of cervix with regard to tumour response, overall and disease free survival.