Role of Cell Block Preparation in Cytopathologic Evaluation of Fine needle aspiration and Body fluids: A Diagnostic Utility

Dr. Ranjan Kumar Mallick; Dr. Harish Chandra Singh; Dr. Anupa Toppo

Volume : IX, Issue : VI, June - 2020

Role of Cell Block Preparation in Cytopathologic Evaluation of Fine needle aspiration and Body fluids: A Diagnostic Utility

Dr. Ranjan Kumar Mallick, Dr. Harish Chandra Singh, Dr. Anupa Toppo

Abstract :

Background: Cell Block preparation with cytological smears from Fine Needle Aspiration Cytology (FNAC) and Body Fluids is simple, reliable, rapid, and cost effective technique to adopt in categorizing lesions whether malignant or benign. Cell block preparation along with conventional smears increases the sensitivity of diagnosis in resource limited laboratories and in guiding towards treatment. Materials and methods: A total of 92 samples were taken into study, which included FNAC, and Body fluids for cell block preparation over a period of two years. Out of 92 samples, 80 samples were included of which 48 were FNAC and 32 were Body Fluids. 12 cases were excluded from the study due to an unsatisfactory sample. Samples were subjected for cell block preparation along with conventional smears. The morphological details and cellular architecture studied and sensitivity of both cell block and conventional smears were determined. Result: FNAC showed 58.3%sensitivity by conventional smears and sensitivity of 87.5% by cell block preparation. In case of body fluids 62.2% sensitivity was observed by conventional smears and 90.6% sensitivity by cell block preparation. Sensitivity and accuracy of cell blocks over conventional smears were greater in all the smears. Conclusion: Cell blocks prepared from the residual tissue after FNAC and sediments of body fluids are always useful in establishing more definitive diagnosis, with an advantage that cell blocks can be used for other ancillary tests whenever required.