Volume : IX, Issue : IV, April - 2020

RNA interference: therapeutic application on COVID 19.

Dr Sonu Namdev, Dr Dileep Dandotiya

Abstract :

It is now believed that control in SARS CoV 2(Covid 19) outeaks is failure in this time all over the world because we have no effective antiviral drugs and vaccine against Covid 19.Hence we required effective, specific, fast, without toxicity to host cell and cost-effective alternative to existing gene targeting technologies both in cell-based and in vivo settings. Only we have one way BIOTECHNOLOGY Method, In which one is RNA interference (RNAi) has been successfully used as a more specific and efficient method for gene silencing. Viruses are formidable targets for drug development. As obligate intracellular parasites that take over the host cellular machinery to further their own agenda, they seem to understand the intimate workings of cellular pathways better than those seeking to develop treatments against them. It is difficult to inactivate a virus without doing harm to the host cell .Only RNAi has become evident that has immense potential in suppression of desired genes. Only in the past decade with the concerted efforts to control the HIV/AIDS epidemic have antiviral drugs come into their own. But now by targeting viral proteins and pathways unique to the viral life cycle, it has become possible to interfere with viral infection and replication for a few viruses without unacceptable host cell toxicity. However, antiviral drugs have only been developed for a handful of viruses, and none of these antiviral drugs is completely effective. Viral resistance, sequence diversity, and drug toxicity are significant problems for all antiviral therapies. In this article, we discuss recent progress and obstacles to harnessing RNA interference to prevent or treat viral infection. Moreover, there is no treatment for most acute viral infections, such as global pandemics caused by newly emerging infections SARS CoV 2(Covid 19) which responsible for global deaths,in the setting of economic development and changing ecology, has made the rapid development of novel antiviral therapies an international priority. It is not surprising, that RNA interference (RNAi) was discovered to work in mammalian cells, researchers honed in on attempts to harness this ancient antiviral mechanism to prevent or treat viral infection. If we are prevent anyone gene translation required for covid 19 life cycle, we are successfully destroy the covid 19.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

RNA INTERFERENCE: THERAPEUTIC APPLICATION ON COVID 19., Dr Sonu Namdev, Dr Dileep Dandotiya GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-9 | Issue-4 | April-2020

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