Renal and liver profile in pre and post menopause women attending OPD of a tertiary health care level institute of Haryana, India.

Dr. R. Tiwari; Indra Prasad Adhikari

Volume : VII, Issue : II, February - 2018

Renal and liver profile in pre and post menopause women attending OPD of a tertiary health care level institute of Haryana, India.

Dr. R. Tiwari, Indra Prasad Adhikari

Abstract :

BACKGROUND: Menopause is a natural step in the process of ageing in a woman‘s life, when her menstruation stops and she is no longer fertile due to depletion of ovarian follicles. Onset of menopause alters the liver functions the most common tests include testing for ALT,AST, Bilirubin and Albumin. Similarly renal function status also alters in terms of urea, creatinine and calcium. Chronic kidney disease (CKD) in women is often accompanied by menstrual and fertility disorders as a consequence of kidney-mediated endocrine disturbances. METHODOLOGY: 50 healthy premenopausal & 50 healthy postmenopausal women were included in study, 5 ml. of venous blood was taken in red vaccutainer and serum was separated. Liver profile and renal profile was estimated by enzymatic method in auto analyser. RESULTS: in the present study the mean values of kidney profile in premenopausal group was found as (in mg/dl) urea (22.22 � 5.07), creatinine,( 0.69 � 0.13) calcium,( 9.73 � 0.60) , phosphorus(3.06 � 0.42) and in postmenopausal group was found as urea( 25.94 � 4.386) , creatinine ( 0.740 � 0.136), calcium (9.89 � 0.598), phosphorus( 3.20 � 0.49) . The p values for this were found as for urea (p= <0.05), for creatinine ( p = 0.115), calcium ( p= 0.185) & for phosphorus(p=0.145) . In present study liver parameters in premenopausal group of women found as (U/L, mean � SD) of SGOT was (24.40 � 4.58) and for SGPT it was found (27.06 � 6.61) & for ALP was found (74.56 � 20.80) and in postmenopausal group these values were found as (28.78 � 5.39),(31.14 � 4.42) & (86.16 � 18.17) respectively.CONCLUSION: This study suggests that there is increase in liver and kidney profile parameters in postmenopausal women as compared to premenopausal women i.e. postmenopausal women have more risk of liver and kidney damage hence a timely health check up must be intensified specially among postmenopausal women.