PTSA Catalysed Expeditious Synthesis and Antimicrobial Activities of Dihydro-3, 5-Diphenylisoxazole Derivatives

Dr. Shalini Jaiswal

Volume : III, Issue : VII, July - 2014

PTSA Catalysed Expeditious Synthesis and Antimicrobial Activities of Dihydro-3, 5-Diphenylisoxazole Derivatives

Dr. Shalini Jaiswal

Abstract :

There is increasing interest in the utility of environmentally benign reagents and particularly solvent-free conditions under microwave irradiation. Chalcone are associated with wide range of biological activities. Chalcone can be modified by the reaction of the substituted benzaldehyde with acetophenone and 10% NaOH under microwave irradiation in domestic oven. This method of synthesis is of great importance and in recent years organic reaction in the absence of solvent has been attracting the synthetic organic chemists because of their simplicity and synthetic value. Organic synthesis without using solvent keeps the environment pollution free by making no use of hazardous solvent like dioxin or strongly acidic and tedious work-up method. This paper describe the use of PTSA as a catalyst in the synthesis of 4,5-dihydro-3,5-diphenylisoxazole derivatives from chalcone and hydroxyl amines hydrochloride under solvent-free condition. The reaction time, yield and 1HNMR spectra are summarized