Protective  Effects  Of  Garlic  Extract  On Cyclophosphamide Induced  Genotoxicity Using Micronucleus Test In  Mice

K. Rudrama Devi; Sri Vani; K.Dilip reddy; Minny Jael.P

Volume : IV, Issue : IX, September - 2015

Protective Effects Of Garlic Extract On Cyclophosphamide Induced Genotoxicity Using Micronucleus Test In Mice

K. Rudrama Devi, Sri Vani, K. Dilip Reddy, Minny Jael. P

Abstract :

In the present investigation the antimutagenic effects of Garlic extract has been evaluated against cyclophosphamide induced genotoxicity. Single IP administration of garlic extract at various doses i.e. 125, 250 and 500 mg /kg . When treated individually did not induce micronuclei in polychromatic erythrocytes of mice. A single Intra peritoneal of 50mg/kg of cyclophosphamide induced significant increase in the percentage of micronuclei in bone marrow cells of mice. However after co administration of three doses of garlic extract there was a dose dependent decrease in the % of micronuclei was observed. Thus the results clearly indicate the protective effects of garlic extract against cyclophosphamide induced genotoxicity in bone marrow cells of mice. Therefore the data indicate that Garlic extract is a safer dietary component in cancer chemo preventive strategy.