PROSPECTIVE DOUBLE BLIND RANDOMIZED STUDY TO COMPARE CLONIDINE AND DEXMEDETOMIDINE IN PREVENTION OF SHIVERING DURING SPINAL ANAESTHESIA

DR. ANIL GUPTA; DR. AMIT DAHIYA; DR. KESHAV CHATURVEDI; DR. MEENAXI SHARMA

Volume : V, Issue : IV, April - 2016

PROSPECTIVE DOUBLE BLIND RANDOMIZED STUDY TO COMPARE CLONIDINE AND DEXMEDETOMIDINE IN PREVENTION OF SHIVERING DURING SPINAL ANAESTHESIA

Dr. Anil Gupta, Dr. Amit Dahiya, Dr. Keshav Chaturvedi, Dr. Meenaxi Sharma

Abstract :

<p>&nbsp;BACKGROUND: This prospective double blind, randomized study was undertaken to compare Clonidine and Dexmedetomidine in prevention of shivering during spinal anaesthesia. Materials and Methods: A total of 100 patients ASA grade I &amp; II between 18-60 years of age, were randomly assigned into one of the two groups, containing 50 patients each. Group C received Clonidine 75 mcg i.v. and Group D received Dexmedetomidine 0.5mcg/kg i.v. both as bolus 5 minutes before subarachnoid block. Perioperative incidence and grade of shivering, level of sedation, hemodynamic parameters and adverse reactions were recorded. RESULTS: There is decrease in both HR and MAP at 20, 40 and 60 min in both groups and the decrease is more in group C compare to group D and was found to be statistically significant (p&lt;0.05). 45(90%) patients in group D developed grade 0 on shivering scale compare to 38(76%) patients in group C, grade 1 developed in 8(16%) patients in group C compare to 3(6%) patients in group D, grade 2 developed in 4(8%) patients in group C in compare to 2(4%) patients in group D and on statistical comparison none is found to be significant (p&gt;0.05).The sedation scores was observed to be higher in group D. Conclusion: Dexmedetomidine may emerge as an alternative to clonidine for prophylaxis of postspinal shivering in short duration cases, with a better sedation profile and better haemodynamic stability.</p>