Profile of Dengue viral Infection in Tertiary Care Hospital in Western Uttar Pradesh

Sadab; Vandana Sardana; Anita Pandey

Volume : VIII, Issue : IV, April - 2019

Profile of Dengue viral Infection in Tertiary Care Hospital in Western Uttar Pradesh

Sadab, Vandana Sardana, Anita Pandey

Abstract :

Background: Dengue is one of most serious arthropod-borne viral infection of humans, caused by a flavivirus. The infection usually occurs with clinical manifestations ranging from an asymptomatic or mild feile illness as classical dengue fever to the potentially life threatening illness, dengue hemorrhagic fever and dengue shock syndrome. Aim & Objectives: To study the frequency of dengue infection in a clinically suspected patients.To determine the laboratory profile of dengue viral infection in patient�s serum.Materials and method: Serum samples from 1714 clinically suspected cases, were processed for the detection of dengue NS1 antigen (Non-structural 1), anti IgM antibodies and anti IgG antibodies using commercial ELISA kit.Result: The frequency of dengue infection was found to be 21.47%, (368/1714). Out of 368 cases, 85.05% were suffering from recent infection and 8.16% were carrying primary infection. Recent secondary infection was present in 2.18% cases and 2.98% had secondary infection. 1.63% cases were infected by dengue virus for the second time or they were suffering from recent secondary infection.Fever was present in all the cases. Other common clinical manifestations were headache, myalgia, retro-orbital pain, sore throat, jaundice and petechiae. Young and middle aged individuals were commonly infected, showing males predominance. Maximum cases were positive in the month of October followed by November, September and August. Conclusion:Dengue is endemic in city population. Early diagnosis of dengue and institution of appropriate supportive therapy may decrease risk of hemorrhage and shock. Climatic and environmental factors should be monitored to control the vector density.