Primary Drug Resistant Pulmonary Tuberculosis in Tertiary care center

Dr. Rakesh Digambar Waghmare; Dr. N. N. Ramraje; Dr. Priti Meshram

Volume : V, Issue : V, May - 2016

Primary Drug Resistant Pulmonary Tuberculosis in Tertiary care center

Dr. Rakesh Digambar Waghmare, Dr. N. N. Ramraje, Dr. Priti Meshram

Abstract :

Introduction:Drug-resistant tuberculosis is a major problem worldwide & is a crucial issue in the control of Tuberculosis. This study is the analysis on the drug resistance profile of M. tuberculosis isolated from patients newly diagnosed with pulmonary TB. Methods:All new cases of Pulmonary Tuberculosis were subjected to sputum smear examination and sputum culture for AFB followed by drugsusceptibility testing by proportion method. Results:Resistance to any drug was seen in 17.49% and multidrug-resistant tuberculosis(MDR-TB) was observed in 3.28%.Primary drug re¬sistance to Isoniazid, Streptomycin Rifampicin and ethambutol was 13.66%, 8.74%, 4.92% and 2.73% respectively. Conclusions:This study suggests that all newly diagnosed cases of Pulmonary Tuberculosis, with AFB smear negativity should also be subjected for AFB culture so as to ascertain active disease. There is a need of continuous monitoring of drug resistance trends, in order to assess the efficacy of current interventions and their impact on the TB epidemic.