Prevalence of Neisseria gonorrhoeae and Other STIs/RTIs with Focus on Gonococcal Phenotypic Antimicrobial Resistance

Mohit Sharma; Meher Rizvi; Richa Gupta; Haris M Khan; Anjum Parvez

Volume : VIII, Issue : VII, July - 2019

Prevalence of Neisseria gonorrhoeae and Other STIs/RTIs with Focus on Gonococcal Phenotypic Antimicrobial Resistance

Mohit Sharma, Meher Rizvi, Richa Gupta, Haris M Khan, Anjum Parvez

Abstract :

Introduction: The aim of this study was to validate microbiologically the spectrum of STIs in a tertiary care centre in North India and to phenotypically detect the antimicrobial resistance in Neisseria gonorrhoeae. Material And Methods:STIs were diagnosed clinically and confirmed by standard laboratory techniques.Antimicrobial resistance pattern of N.gonorrhoeae was determined by standard techniques. Results:Among 201 cases, most common STIs detected were bacterial vaginosis (43.78%) followed by herpes genitalis (25.87%) and candidiasis (16.92%). N.gonorrhoea was identified in 10 (4.98%) patients.Of the 10 confirmed cases of gonorrhoea, antimicrobial sensitivity was performed in 7 patients.All the 7 patients tested were QRNG(Quinolone resistant N.gonorrhoeae),5/7 were PPNG(Penicillinase producing N.gonorrhoeae),1/7 was CMPRNG(Chromosomally mediated penicillin resistant N.gonorrhoeae),3/7 were TRNG(Tetracycline resistant N.gonorrhoeae).MIC by E-test was performed in 5 strains and we observed that MIC90 for ciprofloxacin was ≥4�g/ml,penicillin was ≥6�g/ml,and for tetracycline was 12�g/ml which clearly ackets them as resistant isolates. Conclusion:Alarming increase in the resistance to commonly used antimicrobials for gonorrhoea in our study especially of fluoroquinolones is a clarion call for the urgent need for prudence in prescribing them.