PREVALENCE OF INDUCIBLE CLINDAMYCIN RESISTANCE AMONG COMMUNITY AND HOSPITAL ACQUIRED STAPHYLOCOCCUS AUREUS IN A TERTIARY CARE HOSPITAL.

Nivetha.R; Venkata Raghavendra Rao.A; Reena Rajan

Volume : VII, Issue : VI, June - 2018

PREVALENCE OF INDUCIBLE CLINDAMYCIN RESISTANCE AMONG COMMUNITY AND HOSPITAL ACQUIRED STAPHYLOCOCCUS AUREUS IN A TERTIARY CARE HOSPITAL.

Nivetha. R, Venkata Raghavendra Rao. A, Reena Rajan

Abstract :

Introduction:Staphylococciare one among the most common pyogenic bacteria causing human infection.Clindamycin(a lincosamide) is a useful drug in the treatment of both methicillin sensitive and resistant strains of Staphylococcus.Isolates resistant toMacrolide, Lincosamide and type b Streptogramin(MLSB) antibiotics have increased in number following the widespread use of these antibiotics to treat serious staphylococcal infections.

Objectives:The present study is conducted to determine the prevalence of iMLSB resistance among clinical isolates of Staphylococcus aureus by D test.

Materials & Methods: 50 isolates of Staphylococcus aureusobtained from variousclinical specimens were included in this study.Antibiotic susceptibility test was performed on these isolates by Kirby Bauer disc diffusion method according to CLSI guidelines.Isolates resistant toErythromycin weresubjected toD test to detect inducible resistance.

Results: Of the totalisolates, 26(52%) were Erythromycin resistant.Among the Erythromycin resistant isolates, 7 isolates ,showed inducible clindamycin resistance (D test positive) and one isolate showed constitutive resistanceand 5 isolates showed MS phenotype(D test negative).

Conclusion:Routine susceptibility testing for clindamycin may fail to detect inducible clindamycin resistance in Staphylococcus aureus,hence it is necessary to detect such resistance by D test.