Preparation and Characterization of some Schiff base Macrocylic Ligands of Transition Metal Complexes

Sanjay Kumar Sinha; K. Yadav

Volume : VI, Issue : XI, November - 2017

Preparation and Characterization of some Schiff base Macrocylic Ligands of Transition Metal Complexes

Sanjay Kumar Sinha, K. Yadav

Abstract :

A novel macrocyclic multidentate Schiff base nitrogen donor ligand of transition metal complexes of the type [M(C₁₂H₂₀O₈N₄)C_l2] where M = Cu(II), Ni(II) and Co(II) was prepared via a templet approach and evaluated in vitro for their properties by performing minimum inhibitory concentration (MIC). The multinuclear macrocyclic-based complexes were prepared from the reaction of the corresponding metal chloride with the ligand. The mode of bonding and overall geometry of the compounds were determined through physicochemical and spectroscopic methods. Present study revealed tetrahedral geometry about Cu, Ni and Co atoms. However, square planar geometries have also been suggested for Cu(II) and Ni(II) complexes. Biological activity of the ligand and its metal complexes were studied. Results obtained indicate that growth and ergosterol content decreased significantly in the presence of the test compounds. The ligand offered remarkable viability in the range of 87–94% at a concentration of 25 lM. Ni(II) complex (KNi) was found to be the most active and least cytotoxic among all the compounds screened.