Volume : V, Issue : X, October - 2016

Platelet Storage Lesion. An institutional study

Dr. Subhashish Das, Dr. Harendra Kumar

Abstract :

 Background & objectives: The biochemical, structural and functional changes that occur during platelet storage under blood bank conditions are collectively known as platelet storage lesions (PSL).As EDTA enhances the storageinduced changes, changes in platelet indices with and without EDTA incubation are promising new tests to monitor the PSL. Materials & methods :Morphological changes in platelets were monitored by automated hematological cell counter for platelet count and mean platelet volume (MPV).Samples were incubated with K2EDTA FOR 1 h and platelet indices were repeated on the EDTA incubated samples. Difference between pre-and post-EDTA incubation of platelet count (dPLT) and MPV (Dmpv) were calculated. Results: There was no significant change in the indices without EDTA during storage, however, after EDTA incubation significant changes were noted in dPLT and Dmpv. Interpretation & conclusion: The results indicate that storage induced that storage induced lesions take place even in second generation platelet storage containers under recommended conditions of storage.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Dr. Subhashish Das, Dr. Harendra Kumar Platelet Storage Lesion. An institutional study Global Journal For Research Analysis,Volume-5, Issue-10, October‾2016

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