Personalized therapy versus targeted therapy, differences in the meaning

Ma?gorzata Rogali?ska; Zofia M. Kilia?ska

Volume : IV, Issue : I, January - 2015

Personalized therapy versus targeted therapy, differences in the meaning

Ma Gorzata Rogali Ska, Zofia M. Kilia Ska

Abstract :

The diagnostics and treatment options for numerous cancers are improving and giving the opportunity for increase disease curing efficacy. Unfortunately, the etiology of cancers� transformation is still under investigations. Because of a high number of diverse factors involved in cellular signal trafficking, as well as several metabolic pathways and their potential simultaneous cross–reactivity, choosing the proper type of therapy based on expression of some common changes in marker profile characteristics for a particular type of cancer could not be fully informative, especially for some patients who are resistant to the treatment. There is no doubt that there is a need to transfer from trial–and–error medicine into directed and even more precise towards personalized medicine based on analysis of parameters for a single patient in vivo and in vitro for checking before administration of the potentially effective type of drug(s) to avoid application of ineffective therapy. In this review, we compare the differences between directed and personalized therapy based on our previous studies on chronic lymphocytic leukemia cells versus chronic myelocytic leukemia treatment analysis related to aberrant activity of Bcr–Abl kinase, which is an indication to tyrosine kinase inhibitor – Gleevec application.