Perinatal outcome in women with sickle cell disease/trait

Dr. Mayank R. Patel; Dr. Anjani shrivastava; Dr. Dhwani desai

Volume : III, Issue : XII, December - 2014

Perinatal outcome in women with sickle cell disease/trait

Dr. Mayank R. Patel, Dr. Anjani Shrivastava, Dr. Dhwani Desai

Abstract :

Objectives: To study the perinatal outcome of pregnant women with sickle cell disease and trait. • Methods: This was a prospective observational study in the Obstetrics and gynecology dept, New Civil Hospital, Surat. Pregnant women with Surname: [Thodia, Dubla ,Kokna, Gamit, Chaudhary, Halpati, Vasava, Patel, Nayka, Varni, Kokani, Kathodi, Kolcha, Kotwadia] and all women with anemia attending the Antenatal OPD or admitted to obstetrics ward or labour room were screened for sickle cell anemia. Blood sample of cases that had positive sickling test were subjected to Hb electrophoresis to differentiate SS(SCD) from AS(SCT). 29 SCD and 65 SCT identified and enrolled as subjects in my study. Both group were matched for age, gravidity and other demographic factors. Perinatal outcome as regards birth weight, NICU admission and IUFD was compared in both the groups. Wherever applicable, chisquare test was applied. • Results: Out of 94, sickle cell disease (SS) wasfound in 29 cases (30.85%) and sickle cell trait (AS) in 65cases (69.15%). Prematurity was detected in 46.4% of (SS), and 15.6%of (AS). Low birth weight babies born to SS and AS were respectively 39.3% and 18.7%.Incidence of IUFD was 17.85% in (SS) and 3.12% in (AS). • Conclusions: The incidence of preterm deliveries, IUFD and low birth weight babies are significantly high in women with sickle cell disease compared to sickle cell trait