OVEREXPRESSION of HER2/neu GENE: CORRELATION WITH HISTOLOGICAL GRADING IN BREAST CARCINOMA

Dr. Renu Sahay; Dr. Vikas Goyal; Dr. Shailza

Volume : IX, Issue : I, January - 2020

OVEREXPRESSION of HER2/neu GENE: CORRELATION WITH HISTOLOGICAL GRADING IN BREAST CARCINOMA

Dr. Renu Sahay, Dr. Vikas Goyal, Dr. Shailza

Abstract :

Background: Carcinoma of the east is the most common non- skin malignancy in women. Prognosis and management of east cancer are influenced by variables such as stage, grade, hormone receptor status of oestrogen(ER), progesterone(PR) and Human epidermal growth factor receptor2 (HER2/neu) overexpression. Aim to correlate grade of tumour with HER2/neu receptor status of east carcinoma. Methods: The present study has been conducted in Pathology department, MLB Medical College, Jhansi. The tissue material has been obtained from patients admitted in surgery department for east conservation surgery or modified radical mastectomy and tissue blocks present in pathology department has been utilized. All samples were subjected for routine histological examination and immunohistochemical analysis. Results: The patients were >20 years of age; 56% of tumours were right sided; 51% tumours were histopathologically grade 2 and 98% were invasive east carcinoma. By immunohistochemistry, out of 45 cases, 19 was HER2/neu positive; Out of which the 6 cases (31.57%) with the score of 2+ (grade II), 9 cases (47.37%) with score 3+ (grade III) and 4 cases (21.06%) score of 0/1+ (negative) (grade I). Conclusions: Assessment of hormone receptors for clinical management of east cancer patients is strongly advocated to provide prognostic information and best therapeutic options. A significant correlation was observed between HER2/neu immunoreactivity and the histological grade of tumour.