Olfactory Disfunction In Chronic Kidney Disease Grade 5 Using Sniffin Sticks Test

A. Veronika; Andrina YM Rambe; Siti Nursiah; Fotarisman Zaluchu; Syafrizal Nasution

Volume : VIII, Issue : II, February - 2019

Olfactory Disfunction In Chronic Kidney Disease Grade 5 Using Sniffin Sticks Test

A. Veronika, Andrina Ym Rambe, Siti Nursiah, Fotarisman Zaluchu, Syafrizal Nasution

Abstract :

Background: Smell perception is one of the most important aspects of life, odor perception leads to introduction of different types of food, detection of possible harmful elements and overall quality of life. In chronic kidney disease (CKD), kidneys are disturbed to filter blood so that the body‘s remaining metabolic substances such as urea, uric acid and creatinine can not be excreted. Urea retention may result a smell disturbance by uremic binding OBPs and lipocalins mechanism, thereby saturating olfactory signaling pathways Design: Cross sectional observational study. Methods: A total of 45 patients CKD Grade 5 were included in the study. Olfactory function was assessed for odor threshold, discrimination and identification using Sniffin Sticks Test. Result: The mean of TDI is 26.3 (SD = 4.9). Impaired olfactorydetection was found 64.4% of patients with 27 subjects suffering from hyposmia and 2 subjects suffering from anosmia.