Neurohistopathologicaleffectsofmercury on Hippocampus of Adult Albimo Rat

Brajesh Ranjan; S. M. Dawar Husain; S. M. Yunus

Volume : III, Issue : VII, July - 2014

Neurohistopathologicaleffectsofmercury on Hippocampus of Adult Albimo Rat

Brajesh Ranjan, S. M. Dawar Husain, S. M. Yunus

Abstract :

Mercury is toxic to almost every organ of body, including central nervous system. The aim of present study is to observe the histopathological changes in the hippocampus of rat induced by oral administration of mercuric chloride in adult albino rats. A total number of 20 adult albino rats of either sex were included in the present study,consisting of equal numbers in both control and experimental groups. Experimental group received mercuric chloride in distilled water for aperiod of 15 days, then animals of both groups were anaesthetized with ether and perfused with 10% formalin. Hippocampus was dissected out. 10� thick sections, obtained by usual histological procedure, were stained with H&E. On light microscopic observation, hippocampus from experimental group revealed increased cellularity of neurons with marked pyknosis of nuclei, increased cellularity with highly pleomorphic neuronal cells and markedly hyperchromatic nuclei in the molecular cell layer It was concluded that mercury has toxic effects on the central nervous system including hippocampus which may explain the clinical manifestation of mercury neurotoxicity.