Volume : V, Issue : XII, December - 2016

Neonatal screening in central India for sickle cell anaemia

Dr. Sujata Lall, Dr. A. V. Shrikhande

Abstract :

 Sickle cell disease is an inherited disease of red blood cells. It is characterized by pain episodes, anemia serious infections and damage to vital organs. Symptoms are caused by abnormal hemoglobin.. The sickle gene is prevalent in the tribal populations of India and Carrier frequencies range from 1–40% with the highest prevalence in central India The present study was carried out to estimate the   distribution of sickle cell disease in neonates alongwith their various other   parameters like caste, age geographic region. A targeted approach was taken and mothers affected with hemoglobinopathies were traced in ANC gynaecology wards to collect cord blood during their delivery. 40 such cases were taken and 10 controls gravida matched were taken.The cord blood samples were tested by HPLC and their complete cell count by Automated cell counter. The data showed that 34% newborns were affected with hemoglobinopathies (15FS & 2FS).Mahar caste showed the maximum prevalence 64.7% positive cases while scheduled castes overall showed 70% positive cases, 3 (17.6%) positive cases were found in scheduled tribes, while 1 (5.8%) in Muslim community.

            

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Dr.Sujata lall, Dr.A.V. Shrikhande, Neonatal screening in central India for sickle cell anaemia, Global Journal For Research Analysis,Volume : 5 | Issue : 12 | December 2016

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