Natural Evolution of Experimental  Vitreous Hemorrhage and Effects of  Foreign Body on Its Course

Dragan Vukovic; Antoaneta Adzic

Volume : IV, Issue : XII, December - 2015

Natural Evolution of Experimental Vitreous Hemorrhage and Effects of Foreign Body on Its Course

Dragan Vukovic, Antoaneta Adzic

Abstract :

Introduction :The course and prognosis in vitreous hemorrhage are hard to predict, while its pathogenesis is yet not clear enough, in spite of so far published experimental and clinical studies. Material and methods: The experiment was performed on 19 Chinchilla rabbits (Oryctolagus cuniculus), both male and female (38 eyes), weighting 2500-3000 g, which have been treated with autologous blood (B) from marginal ear vein – the first group, the second group being treated with both , blood and foreign body (B+FB), and the third group treated with blood, corticosteroid and foreign body (B+CS+FB). The control groups were determined by the following approach: for the examined group treated with B+FB+CS, the control group was the one treated with B+FB. We have examined the course of vitreous hemorrhage by making drawings of fundus using indirect ophthalmoscopy, following number and type of cells within the vitreous body (by assessing central and peripheral coagulum, next to ciliary body and retina), fiinolysis, and hemolysis in consecutive time periods of 5 minutes, 6 days, 2, 3, 4, 6, 9, 10 and 12 weeks after intravitreous injection. For this occasion we want just to present the course of fiinolysis. Results: Our results have shown that the fiinolysis of vitreous hemorrhage is slow, compared to hemorrhage in other types of tissue, which is due to composition of the vitreous hyaluronan-collagen matrix which allow limited passage of blood cells that leads to absence of early polymorphonuclear cellular reaction. That leads to persisting of fiin deposits that are normally being degraded by polymorphonuclear cells.