LEVEL OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) URIN AS A PREDICTOR OF ACUTE KIDNEY INJURY IN SEPSIS PATIENTS TREATED IN ICU H.ADAM MALIK MEDAN HOSPITAL

Yudhistira; Burhanuddin Nasution; Achsanuddin Hanafie; Nindia Sugih Arto

Volume : IX, Issue : II, February - 2020

LEVEL OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) URIN AS A PREDICTOR OF ACUTE KIDNEY INJURY IN SEPSIS PATIENTS TREATED IN ICU H.ADAM MALIK MEDAN HOSPITAL

Yudhistira, Burhanuddin Nasution, Achsanuddin Hanafie, Nindia Sugih Arto

Abstract :

Background Sepsis is a complex interaction between the direct toxic effects of infecting microorganisms and the disruption of the host‘s normal inflammatory response to infection. One organ that is often disrupted is the kidney . Neutrophil Gelatinase-Associated Lipocalin (NGAL) is an AKI biomarker that can be used as an early biomarker for AKI prediction, monitoring clinical trials in AKI and for the prognosis of AKI. Method This research is an observational study. 30 subjects with sepsis were examined for PCT, BUN, urea, creatinine and urine NGAL tests. Results Statistical analysis using the Spearman Rank Test shows that NGAL level 1 has a significant relationship with PCT day 1, with a value (r = 0.912) and a value of p <0.05. NGAL level day 1 did not have a significant relationship with levels of urea, creatinine, BUN with values (r = 0.113), (r = 0.329), (r = 0.352) and values (p> 0.05). NGAL day 3 had a significant relationship with PCT day 1, with a value (r = 0.0771) and a p value <0.001. Measurement of NGAL day 3 had a significant relationship with urea, creatinine, BUN, and values (r = 0.427), (r = 0.550), (r = 0.411) with a p value <0.05. Conclusions and recommendations From the results of the study, it was concluded that there was a difference between urine NGAL levels in septic patients on day 1 (197.26 � 118.54) and day 3 (288.31 � 136.96). There was a significant correlation between urinary NGAL levels with urea levels (p = 0.024 & r = 0.427) and creatinine (p = 0.002 & r = 0.550) on day 3, so urine NGAL was a predictor of AKI events in sepsis patients on day 1 -3..