Volume : VII, Issue : III, March - 2018
Laron dwarfism-a rare cause of severe short stature
Arindam Ray, Soumik Goswami, Rahul Valsaraj, Riyas R. S. , Nilanjan Sengupta
Abstract :
Patients with Growth Hormone Insensitivity have characteristic phenotypic features and severe short stature. The underlying basis is mutations in the growth hormone receptor gene. We present a 12-year-old girl evaluated for short stature (-4.8 SDS ) without Turner stigmata . She has sparse hair, depressed nasal idge, mid-facial hypoplasia, high pitched voice. Biochemical analyses revealed normal GH levels with low serum insulin-like growth factor-1(IGF-1). IGF1 generation test revealed growth hormone insensitivity. The massive expense incurred in the diagnosis and treatment with suboptimal therapeutic response necessitates a judicious approach in this regard in a resource limited setup.
Keywords :
Laron Syndrome Dwarfism Micropenis Growth Hormone Insensitivity IGF1 IGFBP3 Recombinant Human Growth Hormone Pituitary Hypoplasia
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DOI : https://www.doi.org/10.36106/gjra
Cite This Article:
Arindam Ray, Soumik Goswami, Rahul Valsaraj, Riyas R.S., Nilanjan Sengupta, Laron dwarfism-a rare cause of severe short stature, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-7, ISSUE-3, MARCH-2018
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References :
Arindam Ray, Soumik Goswami, Rahul Valsaraj, Riyas R.S., Nilanjan Sengupta, Laron dwarfism-a rare cause of severe short stature, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-7, ISSUE-3, MARCH-2018