Volume : VI, Issue : III, March - 2017

INTRAVENOUS FERRIC CAROXYMALTOSE FOR ANAEMIA IN PREGNANCY

Dr. Rekhalatha, Dr. Yogesh Bangera

Abstract :

 Background: Iron deficiency is a very common nutritional deficiency amongst women of reproductive age. Peripartum iron deficiency anaemia (IDA) is associated with significant maternal, fetal and infant morbidity. Currently for treatment are limited: these include oral iron supplementation, which can be ineffective and poorly tolerated, and red blood cell transfusions, which carry an inherent risk and should be avoided. Ferric carboxymaltose is  new treatment option that may be better tolerated.

The study designed to assess the safety and efficacy of iron deficiency anaemia (IDA) correction with intravenous ferric carboxymaltose in pregnant women with mild, moderate and severe anaemia in pregnancy.

Methods: retrospective observational study; 43 anaemic pregnant women received ferric carboxymaltose up to 15 mg/kg between 24 and 40 weeks of pregnancy . Treatment effectiveness was assessed by repeat haemoglobin (Hb) and serum ferritin measurements and patient report of well-being at3rd week. Safety was assessed by analysis of adverse drug reactions and fetal heart rate monitoring during the infusion.

Results: Intravenous ferric carboxymaltose infusion significantly increased Hb values (p < 0.01) above baseline levels in all women. Increased Hb values were observed at 1and 3 weeks post infusion a. Ferritin values increased significantly after the infusion. Fetal heart rate monitoring did not indicate a drug related negative impact on the fetus. Follow-up interview during revisit was conducted on 43 (100%) women at3weeks. Of these women, 35 (81.3%) reported an improvement in their wellbeing (48% reported feeling “much better”, 15% reported “a little better”, and 8(18) reported feeling “no different”) after the infusion. None of the women re- ported feeling worse.

 

Conclusions: Our retrospective data is consistent with existing observational reports of the safe and effective use of ferric carboxymaltose in the treatment of iron deficiency anaemia in pregnancy.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

INTRAVENOUS FERRIC CAROXYMALTOSE FOR ANAEMIA IN PREGNANCY, Dr. Rekhalatha, Dr. Yogesh Bangera GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-6 | Issue-3 | March-2017

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