INCIDENCE OF MICRONUCLEUS  IN EXPOLIATED EPITHELIAL CELLS OF TANNERY WORKERS EXPOSED TO CHROMIUM

Rudrama Devi K

Volume : V, Issue : X, October - 2016

INCIDENCE OF MICRONUCLEUS IN EXPOLIATED EPITHELIAL CELLS OF TANNERY WORKERS EXPOSED TO CHROMIUM

Rudrama Devi K

Abstract :

Chromium (Cr) is widely used industrial chemical. The carcinogenic potential of metals is a major issue of de�ning human health risk from exposure. A study was conducted on a group of population exposed to chromium in tannery industries in Telangana State. The exposure poses a risk to human health and development of several type of cancers. A total of 92 male workers in tannery industry and equal number of control subjects situated at IDA, Jedimelta, Ranga Reddy, District of Telangana. A questionnaire based survey was conducted and buccal smears were collected form oral cavity and analysed for nuclear abnormalities. A high frequency of karolyses was observed among chromium exposed workers. The high percentage of nuclear anonealies were noted in exposed group when compared with longer duration. Smokers in chromium exposed group enhanced the frequency of micronuclei in buccal cells. The present results clearly revealed that chronic occupational exposure to Cr during leather processing could lead to increased levels of DNA damage in exfoliated buccal cells.