Incidence and Antibiotic Resistance patterns of nosocomial Infections caused by Pseudomonas aeruginosa in a Tertiary Hospital, Nashik, India: A Epidemiological Study during 2015-2016

Jagganath D. Andhale; Arun P. More; Aniket Gangurde

Volume : VI, Issue : IV, April - 2017

Incidence and Antibiotic Resistance patterns of nosocomial Infections caused by Pseudomonas aeruginosa in a Tertiary Hospital, Nashik, India: A Epidemiological Study during 2015-2016

Jagganath D. Andhale, Arun P. More, Aniket Gangurde

Abstract :

Backgrounds: P. aeruginosa is major causative organisms of Nosocomial infections. The emergence of drug resistance and its transmission from patients to patients and from healthy persons to patients in ICU is major health concerns before the health workers in India. Moreover the accumulations of number of drug resistance genes in the this organism give limited options for treatment of infections caused by it. Therefore, continued surveillance of drug resistance in this opportunistic pathogen is necessary to plan effective anti-microbial treatment against the infections caused by it. Materials and Methods: From different clinical samples, P.aeruginosa was isolated and identified and tested for drug resistances on suitable media using standard procedures before the start and at the end of Stewardship Program. Statistical analysis was done using R statistical package in Linux system. Results: All the drug tested for drug susceptibility testing show decreased in incidence of drug resistance after a one year time span. Gentamycin show highest decrease of 16.58% followed by ceftazidime at 13.92% and carbenacillin at 12.38%. whereas, the reduction in drug resistance to penicillin and and piperacillin is very low, i.e. only 1.19%. Conclusions: Imipenem, with incidence of drug resistance of 4.13%, was found to be most effective drug and piperacillin and ciprofloxacin , both with incidence of drug resistance of 41.66% were least effective drug against P. aeruginosa in our study in the year 2016.