In-Silico exploration of 4 Aminoquinolines as Lysine Methyltransferase G9a and DNA Methyltransferase inhibitors

P. G. Bansod; N. D. Gawhale

Volume : VIII, Issue : VII, July - 2019

In-Silico exploration of 4 Aminoquinolines as Lysine Methyltransferase G9a and DNA Methyltransferase inhibitors

P. G. Bansod, N. D. Gawhale

Abstract :

Aminoquinolines areheterocyclic molecules with oad range of biological activities. Recently, they were evaluated for Lysine Methyltransferase G9a and DNAMethyltransferase inhibitors inhibitory activity. In the present work, an effort has been made using In-Silico (Bio-informatics approach) to evolve a useful pharmacophoric model using highly active 4 Aminoquinolines for Lysine Methyltransferase G9a and DNAMethyltransferase inhibitors inhibitory activity. The analysis points out that the anti-cancer profile of 4 Aminoquinolines has robust relationship with H-bond acceptor/donor and lipophilic features of the molecules. The analysis could be advantageous for evolving one or more 4 Aminoquinoline derivative with improved anti-cancer activity profile.